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KMID : 0369819960260030201
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Jorunal of Korean Pharmaceutical Sciences
1996 Volume.26 No. 3 p.201 ~ p.205
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Characteristics and Drug Release Control of Crosslinked Poloxamer Hydrogel
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변은정/Byun EJ
이승진/김길수/Lee SJ/Kim KS
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Abstract
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Poloxamer, block copolymers of ethylene oxide and propylene oxide was crosslinked by diisocyanates and triisocyanates to form water-swellable, physically strong, rubber-like elastic, high biocompatible polyurethanes. The isocyanate-hydroxyl stoichiometry was kept 1:1, but the crosslinking density was varied. The variations examined were the ratio of diisocyanate and triisocyanate. The delivery of two drugs of different water solubilities from hydrogel matrices was studied. It appeared that the drug nature greatly influenced its release kinetics possibly due to drug-polymer interactions. The release profiles, however, could be modified to a great extent by adjusting the polymer network structure Generally the high crosslinking density was required for prolonged drug delivery.
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KEYWORD
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Hydrogel, Crosslinked poloxamer, Drug release control, Swelling kinetics
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